Applications of High-Field Asymmetric Waveform Ion Mobility Spectrometry for the Certification of Reference Materials

:High-field asymmetric waveform ion mobility spectrometry (FAIMS), is a novel gas-phase separation technique, developed at the Institute for National Measurement Standards (INMS), and commercialized by Ionaltyics Corporation, ON, Canada (now ThermoFisher). The FAIMS device operates at ambient conditions and is installed between an atmospheric pressure ion source and the mass spectrometer. The first use of FAIMS data in the certification of a reference material was in support of the National Institute of Standards and Technology project to certify ephedrine alkaloids in dietary supplements. FAIMS technology has also been applied to the quantitation of amino acids in a yeast matrix with a view to producing a certified reference material.