Interstitial cystitis: Clinical manifestations and diagnostic criteria in over 200 cases

Abstract Over 200 patients were evaluated for the syndrome of interstitial cystitis. The average patient was found to void 16 times per day with an average volume of 106 ml, nocturia averaged 4–6 times (but 18% of patients voided < 2 times per night) and symptoms were present at least 1 year. Eight‐five percent of the patients were female and 83% had pain. The median age was 44. Cystoscopic changes revealed no carcinoma or carcinoma in situ in 175 patients studied with an average capacity under anesthesia of 561 ml (measured in 175 patients). Only 8% of the patients had ulcers and 89% had glomerulations. Seventy‐five patients had cystometrograms demonstrating an average maximum capacity of 220 ml and an increased sensory urgency in 95% of patients (< 100 ml volume stimulating urgency was considered abnormal). The 90% confidence limit for findings in this disease showed the average voids per day was at least 10, with an average voided volume of < 160 ml, nocturia at least 1–2 per night, duration of symptoms over 1 year, anesthetic bladder capacity of < 850 ml.