Copper and copper nanoparticles toxicity and their impact on basic functions in the body
Токсичность меди и медных наночастиц и их влияние на основные функции организма
2019-01-01
SCID: 54.1/z9gt6696
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Fenton reactionWilson diseasecopper nanoparticle toxicityneurodegenerative disordersreactive oxygen species
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Abstract (AI)
Copper is a biogenic metal having multiple functions in basic processes in organisms and it is common in all kingdoms of life. Limited intake of copper is a problem; however, doses of copper exceeding the recommended alimentary source are problematic as well and toxicity is soon manifested. Impact of copper nanoparticles on human health is another serious issue taken into consideration in this review. Regarding to copper toxicity, neurodegenerative disorders including Alzheimer and Parkinson diseases are suspected to be linked to copper toxicity or copper can contribute to their progression. Wilson and Menke diseases are also described as examples of copper intolerance. This paper is focused on the description, literature survey and discussion of the current knowledge about copper and copper nanoparticles toxicity and their involvement in various pathological processes (Tab. 6, Fig. 2, Ref. 171). Keywords: reactive oxygen species; Alzheimer disease; acetylcholinesterase; copper; Fenton reaction; disorder; heavy metal; pollution; nanoparticle.
Key Findings
1
Copper is essential for basic biological processes across all kingdoms of life, but both insufficient and excessive intake can cause adverse effects.
2
Copper nanoparticles represent an additional human-health concern, with the review examining their toxicity and involvement in pathological processes.
3
Copper toxicity develops when exposure exceeds recommended dietary levels, demonstrating a narrow margin between nutritional requirement and toxicity.
4
Copper toxicity may be associated with neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases or contribute to their progression.
5
Wilson disease and Menkes disease are described as examples of disorders involving copper intolerance or dysregulation.
Research Object
copper and copper nanoparticles in biological organisms, including humans
Research Subject
their toxicity, effects on basic bodily functions, and involvement in pathological processes
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2019-01-01
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