Rational Manipulation of Carrier‐Domain Geometry in Nonribosomal Peptide Synthetases

Changing the assembly line. Nonribosomal peptide synthetases are multidomain enzyme assemblies responsible for the biosynthesis of a wide range of therapeutically important natural products. Here we describe an approach to construct stable, domain-specific conjugates of nonribosomal peptide synthetases by using synthetic analogues of coenzyme A.