Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Béla Melegh, Xuebin Zheng, Joseph D. Buxbaum, Jan Lubiński, Ariel Darvasi, Naomi R. Wray, Peter M. Visscher, Steven A. McCarroll, Sang Lee, Shaun Purcell, Alkes L. Price, Benjamin M. Neale, Mark J. Daly, Pak C. Sham, Stanley V. Catts, Menachem Fromer, Douglas M. Ruderfer, Christina M. Hultman, Aarno Palotie, Pamela Sklar, Patrick F. Sullivan, Andrew McQuillin, Peter Holmans, John Powell, Nigel Williams, Michael J. Owen, Hreinn Stefánsson, Kāri Stefánsson, Dominique Campion, Michael Gill, Michael O‘Donovan, Stacy Steinberg, Ole A. Andreassen, Srdjan Djurovic, Per Hoffmann, Wolfgang Maier, Stefan Herms, Ina Giegling, Valentina Escott‐Price, Stephan Ripke, Daniëlle Posthuma, Mari Nelis, Andres Metspalu, Michael H. Davidson, Giulio Genovese, David M. Hougaard, Anders D. Børglum, Ole Mors, Preben Bo Mortensen, Anil K. Malhotra, Robin Murray, Daniel R. Weinberger, John L. Waddington, Tao Li, Joshua L. Roffman, Jordan W. Smoller, Randy L. Buckner, James Walters, Ann Olincy, Robert Freedman, Abraham Reichenberg, Johan G. Eriksson, Peter Eichhammer, Marcella Rietschel, Erik G. Jönsson, Robert W. McCarley, Edward M. Scolnick, Chongzhi Zang, Kai-How Farh, Soumya Raychaudhuri, Gosia Trynka, Jim van Os, Christian Schubert, Jurgen Del‐Favero, Lude Franke, Timothy G. Dinan, Josef Frank, Stephanie H. Witt, Hilary K. Finucane, Jianjun Liu, Fritz Zimprich, Hailiang Huang, Thomas G. Schulze, T. Scott Stroup, Donald W. Black, Han Xu, Juha Veijola, Siow Ann Chong, Mythily Subramaniam, Chris C. A. Spencer, Colm O’Dushlaine, Panos Roussos, Bogdan Paşaniuc, Juha Karjalainen, Ditte Demontis, Dan Rujescu, Alexander Gusev, Tim B. Bigdeli, Jakob Grove, Tõnu Esko, Lili Milani, Steve McCarroll, Hon‐Cheong So, Eli A. Stahl, Bryan Mowry, Michele T. Pato, Esben Agerbo, Eric Chen, Kristin K. Nicodemus, Patricia T. Michie, Milan Maçek, Brian Kelly, James A. Knowles, Hannelore Ehrenreich, Rodney J. Scott, Patrik K. E. Magnusson, James L. Kennedy, Joel N. Hirschhorn, Tune H. Pers, Brendan Bulik‐Sullivan, Andrew M. McIntosh, Jennifer L. Moran, Anna K. Kähler, Susanne Akterin, Sarah E. Bergen, James J. Crowley, Yunjung Kim, Stephanie Williams, Paul Cormican, Nick Craddock, Naser Durmishi, В. Е. Голимбет, Marian L. Hamshere, Kenneth S. Kendler, Derek W. Morris, F. Anthony O’Neill, Alexander Richards, Brien P. Riley, Engilbert Sigurðsson, Teimuraz Silagadze, Jaana Suvisaari, Sarah Tosato, Elvira Bramon, Aiden Corvin, Vahram Haroutunian, Enrico Domenici, Thomas Folkmann Hansen, Thomas Werge, Qingqin S. Li, Rita M. Cantor, Guiqing Cai, Jing Wu, Andrew Pocklington, Lyudmila Georgieva, Noa Carrera, Vihra Milanova, Kimberly Chambert, George Kirov, Jacqueline I. Goldstein, Larry J. Seidman, Elodie Drapeau, Jacob Gratten, Matthew C. Keller, Gary Donohoe, Richard E. Straub, David Cohen, Richard Bruggeman, Annette M. Hartmann, Silviu‐Alin Bacanu, Lynn E. DeLisi, Roel A. Ophoff, Sven Cichon, Judit Bene, Sena Karachanak-Yankova, Vaidutis Kučinskas, Драга Тончева, Jo Knight, Younes Mokrab, Qiang Wang, David Collier, Jacques Mallet, Veikko Salomaa, Jin Szatkiewicz, Kenneth L. Davis, Inez Myin‐Germeys, Frank Dudbridge, Kang Sim, Nelson B. Freimer, Carlos N. Pato, Ann E. Pulver, Eric Strengman, Miaoxin Li, David Curtis, René S. Kahn, Margot Albus, Tiina Paunio, Bjarni J. Vilhjálmsson, Pablo V. Gejman, Jubao Duan, Alan R. Sanders, Masashi Ikeda, Nakao Iwata, Hualin Simon Xi, Jens R. Wendland, Bettina Konte, Todd Lencz, Douglas Blackwood, Vaughan J. Carr, Mark Weiser, Dermot Walsh, Manuel Mattheisen, Jānis Kloviņš, Emily Wong, Digby Quested, Hugh Gurling, Laurent Essioux, Kimberly D. Chambert, Phil Lee, Elizabeth Bevilacqua, Tracey L. Petryshen, Richard A. Belliveau, David Kavanagh, Sophie E. Legge, Morten Mattingsdal, Ingrid Melle, Henrik B. Rasmussen, Madeline Alexander, Claudine Laurent, Douglas F. Levinson, Bradley T. Webb, Christian Hammer, Martin Begemann, Sergi Papiol, Nancy G. Buccola, Wiepke Cahn, Elena Parkhomenko, Joseph I. Friedman, Christos Pantelis, Ulrich Schall, Raymond Chan, Ronald Y.L. Chen, Wei Cheng, Eric Cheung, Dragan M. Švrakić, Nadine Cohen, Martilias S. Farrell, Franziska Degenhardt, George N. Papadimitriou, Dimitris Dikeos, Ayman H. Fanous, Marion Friedl, Stephanie Godard, Srihari Gopal, Dai Wang, Lieuwe de Haan, Carin J. Meijer, Mads V. Hollegaard, Inge Joa, Sara Marsal, Antonio Julià, Clement C. Zai, P. A. Slominsky, Andrey Khrunin, Liene Ņikitina-Zaķe, Zita Aušrelė Kučinskienė, Hana Kuzelova-Ptackova, Bernard Lerer, Jeffrey A. Lieberman, Brion S. Maher, Kieran C. Murphy, Igor Nenadić, Deborah A. Nertney, Gerald Nestadt, Laura Nisenbaum, Annelie Nordin, Rolf Adolfsson, Milica Pejović-Milovančević, Diana O. Perkins, Mark A. Reimers, Aaron R. Wolen, Elisabeth Stögmann, Srinivas Thirumalai, Dieter B. Wildenauer, Assen Jablensky, David St Clair, Ingrid Agartz, Jana Strohmaier, Jonathan Pimm, William Byerley, Paul A. Tooney, Elliot S. Gershon, Frans A. Henskens, Carmel M. Loughland, Colm McDonald, Luba Kalaydjieva, Sandra Meier, Line Olsen, C. Robert Cloninger, Mark Hansen, Raquelle I. Mesholam‐Gately, Farooq Amin, Jeremy M. Silverman, Jianxin Shi, Svetlana Limborska, Paola Giusti-Rodrguez, Andrea Hofman, Jimmy Lee Chee Keong, Kung-Yee Liang, Jouko Lnnqvist, Bertram Mller-Myhsok, Eadbhard O’Callaghan, Sang-Yun Oh, Olli Pietilinen, Sibylle G. Schwab, Erik Sderman, Brandon K. Wormley, Anders D. B�rglum, Markus M. Nthen

2014-11-01

SCID: 54.1/zmcnehcv

Publication Details

DOI

10.1016/j.ajhg.2014.10.004

Publication Date

2014-11-01

Journal

Publisher

ISSN

Access Type

Author Information

Authors

Béla Melegh

Xuebin Zheng

Joseph D. Buxbaum

Jan Lubiński

Ariel Darvasi

Naomi R. Wray

Peter M. Visscher

Steven A. McCarroll

Sang Lee

Shaun Purcell

Alkes L. Price

Benjamin M. Neale

Mark J. Daly

Pak C. Sham

Stanley V. Catts

Menachem Fromer

Douglas M. Ruderfer

Christina M. Hultman

Aarno Palotie

Pamela Sklar

Patrick F. Sullivan

Andrew McQuillin

Peter Holmans

John Powell

Nigel Williams

Michael J. Owen

Hreinn Stefánsson

Kāri Stefánsson

Dominique Campion

Michael Gill

Michael O‘Donovan

Stacy Steinberg

Ole A. Andreassen

Srdjan Djurovic

Per Hoffmann

Wolfgang Maier

Stefan Herms

Ina Giegling

Valentina Escott‐Price

Stephan Ripke

Daniëlle Posthuma

Mari Nelis

Andres Metspalu

Michael H. Davidson

Giulio Genovese

David M. Hougaard

Anders D. Børglum

Ole Mors

Preben Bo Mortensen

Anil K. Malhotra

Robin Murray

Daniel R. Weinberger

John L. Waddington

Tao Li

Joshua L. Roffman

Jordan W. Smoller

Randy L. Buckner

James Walters

Ann Olincy

Robert Freedman

Abraham Reichenberg

Johan G. Eriksson

Peter Eichhammer

Marcella Rietschel

Erik G. Jönsson

Robert W. McCarley

Edward M. Scolnick

Chongzhi Zang

Kai-How Farh

Soumya Raychaudhuri

Gosia Trynka

Jim van Os

Christian Schubert

Jurgen Del‐Favero

Lude Franke

Timothy G. Dinan

Josef Frank

Stephanie H. Witt

Hilary K. Finucane

Jianjun Liu

Fritz Zimprich

Hailiang Huang

Thomas G. Schulze

T. Scott Stroup

Donald W. Black

Han Xu

Juha Veijola

Siow Ann Chong

Mythily Subramaniam

Chris C. A. Spencer

Colm O’Dushlaine

Panos Roussos

Bogdan Paşaniuc

Juha Karjalainen

Ditte Demontis

Dan Rujescu

Alexander Gusev

Tim B. Bigdeli

Jakob Grove

Tõnu Esko

Lili Milani

Steve McCarroll

Hon‐Cheong So

Eli A. Stahl

Bryan Mowry

Michele T. Pato

Esben Agerbo

Eric Chen

Kristin K. Nicodemus

Patricia T. Michie

Milan Maçek

Brian Kelly

James A. Knowles

Hannelore Ehrenreich

Rodney J. Scott

Patrik K. E. Magnusson

James L. Kennedy

Joel N. Hirschhorn

Tune H. Pers

Brendan Bulik‐Sullivan

Andrew M. McIntosh

Jennifer L. Moran

Anna K. Kähler

Susanne Akterin

Sarah E. Bergen

James J. Crowley

Yunjung Kim

Stephanie Williams

Paul Cormican

Nick Craddock

Naser Durmishi

В. Е. Голимбет

Marian L. Hamshere

Kenneth S. Kendler

Derek W. Morris

F. Anthony O’Neill

Alexander Richards

Brien P. Riley

Engilbert Sigurðsson

Teimuraz Silagadze

Jaana Suvisaari

Sarah Tosato

Elvira Bramon

Aiden Corvin

Vahram Haroutunian

Enrico Domenici

Thomas Folkmann Hansen

Thomas Werge

Qingqin S. Li

Rita M. Cantor

Guiqing Cai

Jing Wu

Andrew Pocklington

Lyudmila Georgieva

Noa Carrera

Vihra Milanova

Kimberly Chambert

George Kirov

Jacqueline I. Goldstein

Larry J. Seidman

Elodie Drapeau

Jacob Gratten

Matthew C. Keller

Gary Donohoe

Richard E. Straub

David Cohen

Richard Bruggeman

Annette M. Hartmann

Silviu‐Alin Bacanu

Lynn E. DeLisi

Roel A. Ophoff

Sven Cichon

Judit Bene

Sena Karachanak-Yankova

Vaidutis Kučinskas

Драга Тончева

Jo Knight

Younes Mokrab

Qiang Wang

David Collier

Jacques Mallet

Veikko Salomaa

Jin Szatkiewicz

Kenneth L. Davis

Inez Myin‐Germeys

Frank Dudbridge

Kang Sim

Nelson B. Freimer

Carlos N. Pato

Ann E. Pulver

Eric Strengman

Miaoxin Li

David Curtis

René S. Kahn

Margot Albus

Tiina Paunio

Bjarni J. Vilhjálmsson

Pablo V. Gejman

Jubao Duan

Alan R. Sanders

Masashi Ikeda

Nakao Iwata

Hualin Simon Xi

Jens R. Wendland

Bettina Konte

Todd Lencz

Douglas Blackwood

Vaughan J. Carr

Mark Weiser

Dermot Walsh

Manuel Mattheisen

Jānis Kloviņš

Emily Wong

Digby Quested

Hugh Gurling

Laurent Essioux

Kimberly D. Chambert

Phil Lee

Elizabeth Bevilacqua

Tracey L. Petryshen

Richard A. Belliveau

David Kavanagh

Sophie E. Legge

Morten Mattingsdal

Ingrid Melle

Henrik B. Rasmussen

Madeline Alexander

Claudine Laurent

Douglas F. Levinson

Bradley T. Webb

Christian Hammer

Martin Begemann

Sergi Papiol

Nancy G. Buccola

Wiepke Cahn

Elena Parkhomenko

Joseph I. Friedman

Christos Pantelis

Ulrich Schall

Raymond Chan

Ronald Y.L. Chen

Wei Cheng

Eric Cheung

Dragan M. Švrakić

Nadine Cohen

Martilias S. Farrell

Franziska Degenhardt

George N. Papadimitriou

Dimitris Dikeos

Ayman H. Fanous

Marion Friedl

Stephanie Godard

Srihari Gopal

Dai Wang

Lieuwe de Haan

Carin J. Meijer

Mads V. Hollegaard

Inge Joa

Sara Marsal

Antonio Julià

Clement C. Zai

P. A. Slominsky

Andrey Khrunin

Liene Ņikitina-Zaķe

Zita Aušrelė Kučinskienė

Hana Kuzelova-Ptackova

Bernard Lerer

Jeffrey A. Lieberman

Brion S. Maher

Kieran C. Murphy

Igor Nenadić

Deborah A. Nertney

Gerald Nestadt

Laura Nisenbaum

Annelie Nordin

Rolf Adolfsson

Milica Pejović-Milovančević

Diana O. Perkins

Mark A. Reimers

Aaron R. Wolen

Elisabeth Stögmann

Srinivas Thirumalai

Dieter B. Wildenauer

Assen Jablensky

David St Clair

Ingrid Agartz

Jana Strohmaier

Jonathan Pimm

William Byerley

Paul A. Tooney

Elliot S. Gershon

Frans A. Henskens

Carmel M. Loughland

Colm McDonald

Luba Kalaydjieva

Sandra Meier

Line Olsen

C. Robert Cloninger

Mark Hansen

Raquelle I. Mesholam‐Gately

Farooq Amin

Jeremy M. Silverman

Jianxin Shi

Svetlana Limborska

Paola Giusti-Rodrguez

Andrea Hofman

Jimmy Lee Chee Keong

Kung-Yee Liang

Jouko Lnnqvist

Bertram Mller-Myhsok

Eadbhard O’Callaghan

Sang-Yun Oh

Olli Pietilinen

Sibylle G. Schwab

Erik Sderman

Brandon K. Wormley

Anders D. B�rglum

Markus M. Nthen

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