Insight into Vaccine Development for Alphacoronaviruses Based on Structural and Immunological Analyses of Spike Proteins

Jiale Shi, Yanan Fu, Gang Wang, Guangli Hu, Zhen F. Fu, Yuejun Shi, Guiqing Peng, Shaobo Xiao, Limeng Sun, Yubei Tan, Fenglin Guo
2021-01-08

SCID:  54.1/zqq9tw7e
(HCoV-229E) with a RBD "lying" state, the S-trimer may be more suitable for subunit vaccines than the RBD. Our results will provide novel ideas for the development of vaccines targeting S protein in the future.
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2021-01-08
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Jiale Shi
Yanan Fu
Gang Wang
Guangli Hu
Zhen F. Fu
Yuejun Shi
Guiqing Peng
Shaobo Xiao
Limeng Sun
Yubei Tan
Fenglin Guo
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