An integrated encyclopedia of DNA elements in the human genome
Интегрированная энциклопедия элементов ДНК генома человека
2012-09-01
SCID: 54.1/zxgsbq9n
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ENCODE projectchromatin structurefunctional genome annotationgene regulatory elementsgenome-wide association studies
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Abstract (AI)
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor association, chromatin structure and histone modification. These data enabled us to assign biochemical functions for 80% of the genome, in particular outside of the well-studied protein-coding regions. Many discovered candidate regulatory elements are physically associated with one another and with expressed genes, providing new insights into the mechanisms of gene regulation. The newly identified elements also show a statistical correspondence to sequence variants linked to human disease, and can thereby guide interpretation of this variation. Overall, the project provides new insights into the organization and regulation of our genes and genome, and is an expansive resource of functional annotations for biomedical research. This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription-factor association, chromatin structure and histone modification. In this overview, the Consortium guides the readers through the project itself, the data and their integrated analyses. Eighty per cent of the human genome now has at least one biochemical function assigned to it. In addition to expanding our understanding of how gene expression is regulated on a genome-wide scale, the newly identified functional elements should help researchers to interpret the results of genome-wide associated studies because many correspond to sites associated with human disease.
Key Findings
1
Integrated ENCODE data assigned at least one biochemical function to 80% of the human genome, especially regions outside protein-coding sequences.
2
Many candidate regulatory elements are physically associated with each other and with expressed genes, revealing genome-wide patterns of gene regulation.
3
Newly identified functional elements statistically correspond to genetic variants associated with human disease, aiding interpretation of genome-wide association studies.
4
The ENCODE project systematically mapped transcription, transcription-factor binding, chromatin structure, and histone modifications across the human genome.
5
The project provides an expansive functional-annotation resource for studying human genome organization, regulation, and biomedical variation.
Research Object
DNA elements in the human genome
Research Subject
the genome-wide biochemical functions, organization, and regulatory relationships of DNA elements, including their links to gene expression and human-disease-associated variants
Publication Details
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2012-09-01
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