Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates
Модели животных для COVID-19: хомяки, мыши, хорьки, норки, древесные шрекеры и негуманные приматы
2021-08-31
SCID: 54.1/2ad4sy4h
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SARS-CoV-2 animal modelsferret modelhamster modelmouse modelnon-human primates
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Abstract (AI)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus causing acute respiratory tract infection in humans. The virus has the characteristics of rapid transmission, long incubation period and strong pathogenicity, and has spread all over the world. Therefore, it is of great significance to select appropriate animal models for antiviral drug development and therapeutic effect evaluation. Here, we review and compare the current animal models of SARS-CoV-2.
Key Findings
1
SARS-CoV-2 causes acute respiratory tract infection in humans and exhibits rapid transmission, long incubation, and strong pathogenicity.
2
Selecting appropriate animal models is critically important for antiviral drug development and therapeutic evaluation for COVID-19.
3
The paper synthesizes information to guide choice of animal models for studying SARS-CoV-2 pathogenesis and testing interventions.
4
The review compares current SARS-CoV-2 animal models including hamsters, mice, ferrets, mink, tree shrews, and non-human primates.
Research Object
Animal models of SARS-CoV-2 (hamsters, mouse, ferret, mink, tree shrew, and non-human primates)
Research Subject
Comparative evaluation of these animal models for suitability in antiviral drug development and therapeutic efficacy assessment for COVID-19
Publication Details
Publication Date
2021-08-31
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