Genes polymorphisms of transforming growth factor β1 and matrix metalloproteinase 9 as molecular and genetic predictors of isthmic-cervical insufficiency development in female patients with undifferentiated connective tissue dysplasia

Полиморфизмы генов трансформирующего фактора роста β1 и матричной металлопротеиназы 9 как молекулярно‑генетические предикторы развития истмико‑цервикальной недостаточности у женщин с недифференцированной дисплазией соединительной ткани
I.S. Kononenko
2020-06-01
SCID:  54.1/6b2a36yc Discuss with AI
A-8202G (rs11697325) polymorphismArg25Pro (rs1800471) polymorphismisthmic-cervical insufficiencymatrix metalloproteinase 9 (MMP9)transforming growth factor β1 (TGF1)undifferentiated connective tissue dysplasia
Abstract (AI)
() ( 53% 68,8%), - (). - A-8202G (rs11697325) 9 (9) Arg25Pro (rs1800471) 1 (TGF1) . . - 71 22-24 . -36 , -35 . -, . - (-) - TGF1, 9, , . TGF1 9 (). . -8202G (G/G) A-8202G 9 (O=4,00; 95% 1,23-12,98; p=0,02) (Arg/Pro) Arg25Pro TGF1 (O=3,75; 95% 1,47; p<0,0001). , TGF1 9 . . G/G A-8202G (rs11697325) 9 Arg/Pro Arg25Pro (rs1800471) TGF1 .
Key Findings
1
Arg25Pro (rs1800471) TGF1 genotype (Arg/Pro) is associated with higher risk of isthmic-cervical insufficiency (OR=3.75; 95% CI 1.47; p<0.0001)
2
Combined presence of TGF1 A-8202G G/G genotype and Arg25Pro Arg/Pro genotype denotes a genetic predisposition to developing isthmic-cervical insufficiency in the studied cohort
3
Polymorphism A-8202G (rs11697325) in TGF1 is associated with increased risk of isthmic-cervical insufficiency (OR=4.00; 95% CI 1.23–12.98; p=0.02) in women with undifferentiated connective tissue dysplasia
4
Study examined female patients with undifferentiated connective tissue dysplasia and identified TGF1 gene polymorphisms as molecular-genetic predictors of isthmic-cervical insufficiency
Research Object

Polymorphisms of TGF-β1 and MMP-9 genes in female patients with undifferentiated connective tissue dysplasia

Research Subject

Association of specific TGF-β1 (A-8202G/rs11697325, Arg25Pro/rs1800471) and MMP-9 gene polymorphisms with risk/prediction of isthmic-cervical insufficiency development

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2020-06-01
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I.S. Kononenko
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