Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

Обзор проекта «Атлас генома рака» (TCGA): неисчерпаемый источник знаний
Maciej Wiznerowicz, Katarzyna Tomczak, Patrycja Czerwińska
2015-01-01
SCID:  54.1/h34a4j8z Discuss with AI
The Cancer Genome Atlas (TCGA)cancer genomic profileslarge-scale genome sequencingpan-cancer analysestumorigenesis
Abstract (AI)
The Cancer Genome Atlas (TCGA) is a public funded project that aims to catalogue and discover major cancer-causing genomic alterations to create a comprehensive "atlas" of cancer genomic profiles. So far, TCGA researchers have analysed large cohorts of over 30 human tumours through large-scale genome sequencing and integrated multi-dimensional analyses. Studies of individual cancer types, as well as comprehensive pan-cancer analyses have extended current knowledge of tumorigenesis. A major goal of the project was to provide publicly available datasets to help improve diagnostic methods, treatment standards, and finally to prevent cancer. This review discusses the current status of TCGA Research Network structure, purpose, and achievements.
Key Findings
1
Individual cancer studies and pan-cancer analyses from TCGA have expanded understanding of tumorigenesis.
2
TCGA provides publicly available datasets intended to improve cancer diagnosis, treatment standards, and ultimately prevention.
3
TCGA researchers have analyzed large cohorts spanning more than 30 human tumor types using large-scale genome sequencing and integrated multidimensional analyses.
4
The Cancer Genome Atlas (TCGA) systematically catalogues major cancer-causing genomic alterations to build comprehensive cancer genomic profiles.
5
The review summarizes the TCGA Research Network’s structure, purpose, and major achievements.
Research Object

The Cancer Genome Atlas (TCGA) project and its publicly available cancer genomic datasets

Research Subject

The TCGA Research Network’s structure, purpose, achievements, and contribution to characterizing cancer-causing genomic alterations across human tumor types

Publication Details
Publication Date
2015-01-01
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Author Information
Authors
Maciej Wiznerowicz
Katarzyna Tomczak
Patrycja Czerwińska
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