Integrated genomic analyses of ovarian carcinoma

Stephen B. Baylin; Tim Fennell; John N. Weinstein; Anil K. Sood; Peter J. Park; Liwei Lin; Rae Myers; W. K. Alfred Yung; Cameron Brennan; Houtan Noushmehr; Zack Sanborn; Chang‐Jiun Wu; Sachet A. Shukla; Giovanni Ciriello; Carrie Sougnez; Mary Iacocca; Daniel J. Weisenberger; Robert Penny; Charles M. Perou; D. Neil Hayes; Richard A. Gibbs; Eric S. Lander; Paul T. Spellman; Chris Sander; Matthew Meyerson; Stacey Gabriel; David Haussler; Christopher C. Benz; Brenda Rabeno; Eunjung Lee; Joseph Paulauskis; Troy Shelton; Mark E. Sherman; Peggy Yena; Saianand Balu; Katherine A. Hoadley; Michael D. Topal; Yevgeniy Antipin; Laetitia Borsu; Ethan Cerami; Marc Ladanyi; Alex Lash; Yupu Liang; Boris Reva; Nikolaus Schultz; Agnès Viale; Martin L. Ferguson; Mark S. Guyer; Bradley A. Ozenberger; Mark A. Jensen; A Kahn; Mike Noble; Kristian Cibulskis; Michael S. Lawrence; Robert C. Onofrio; Gordon Saksena; Lucinda Fulton; Elaine R. Mardis; Joshua M. Stuart; Rehan Akbani; David Van Den Berg; John Ngai; Elizabeth Purdom; Joseph R. Testa; Rui Jing; Andrey Sivachenko; Lisa L. Cook; Sherri Z. Millis; Janet S. Rader; David G. Huntsman; Keith Baggerly; Gavin Sherlock; Terence P. Speed; Joe W. Gray; Alex H. Ramos; George M. Weinstock; Mei Huang; G.B. Mills; J. M. Greene; Marcin Imieliński; Hani Gabra; Kristin Ardlie; Peter J. Good; Kay J. Park; Fanny Dao; Douglas A. Levine; Debra Bell; Jennifer Baldwin; Kim D. Delehaunty; Donna M. Muzny; Jane L. Peterson; Carl Morrison; Zhiyuan Hu; Daniel C. Koboldt; David A. Wheeler; Vincent Magrini; David J. Dooling; Catrina C. Fronick; Lora Lewis; Irene Newsham; Craig Pohl; David D.L. Bowtell; Andrew Berchuck; Benjamin P. Berman; Jeremy Chien; Leslie Cope; Rajiv Dhir; Michael D. McLellan; Nicholas J. Petrelli; Benjamin J. Raphael; Heather K. Schmidt; Karen Smith‐McCune; Douglas Voet; Matthew D. Wilkerson; Yuanyuan Xiao; Christopher Yau; Jin Xu; Alicia Hawes; Julian K. Wu; Dae Young Zang; Scott Morris; Christopher Harris; Carolyn C. Compton; Jinghui Zhang; Wendy Winckler; Ryan Demeter; Preethi H. Gunaratne; Craig H. Mermel; Cyriac Kandoth; John W. Wallis; Nathan D. Dees; Roeland Verhaak; Barry S. Taylor; Huyen Dinh; Steffen Durinck; Junwei Han; Charles Vaske; Timothy J. Triche; Rachel Karchin; Branimir I. Šikić; John R. Walker; Fabio Vandin; Henrik Bengtsson; Pierre Neuvial; William Schierding; Huy Nguyen; Raju Kucherlapati; Michael J. Birrer; Jireh Santibanez; Philip J. DiSaia; Pat Glenn; D. W. Cramer; Narciso Olvera; D. A. Levine; A. K. Godwin; Sandra Oršulić; Beth Y. Karlan; Jenny Gross; L Hartmann; Steve E. Kalloger; G. B. Mills; J. N. Weinstein; C. Morrison; D. Mutch; Michael J Hatfield; Paul Rhodes; Donata Grimm; Y.-Q. Wu; Jennifer Drummond; M. B. Morgan; C. Kovar; Kuo-Ching Chang; Lisa R. Treviño; C. J. Creighton; Gerald Fowler; M. Wang; J. G. Reid; G. Getz; C. H. Mermel; K. Cibulskis; R. W. Park; S. L. Carter; L. Chin; Andrew Crenshaw; Gaddy Getz; R. G. W. Verhaak; Sumeet Gupta; Diana Hubbard; James G. Herman; Stephen C. Benz; Christopher Szeto; Jingchun Zhu; Lakshmi R. Jakkula; Heidi S. Feiler; Robert E. Sheridan; Peter W. Laird; John G. Conboy; Joelle Kalicki; James M. Eldred; Lindsay L. Waite; Laura M. Heiser; James E. Korkola; James D. Brooks; Shelley Alonso; Parminder K. Mankoo; Fei Pan; R. Nichol; Jennifer Wilkinson; Theodora Bloom; T. Wylie; Q. Zhang; Ryan Abbott; M. Wendl; Dejun Shen; L. Ding; M. O’Laughlin; R. S. Fulton; S. M. Smith; Rebecca K. Wilson; James S. Hodges; E. Upfal; A. H. Ramos; Hangchao Zhang; Ilana Perna; Junihua Zhang; Lawrence S. Chin; Juinhua Zhang; Alex Protopopov; Gang Ren; Y. Liu; T. M. Kim; Narayanan Sathiamoorthy; Devin Absher; J. Z. Li; H. Shen; Jermya Buckley; Bahram Parvin; Raymond J. Cho; T. P. Speed; Helen Marr; Nihan Wang; Shannon Dorton; P. Neuvial; Yeseo Choi; Vanessa Wang; Wan Chang; Nick Socci; K. A. Hoadley; Peter L. Fielding; Rachel C. Myles; M. D. Topal; Y. Du; C. M. Perou; D. N. Hayes; L. Li; Erin Helms; Yidi J. Turman; Y. Eric Shi; Shiyu Meng; X. Zhou; H. Carter; D. Kim; J. Samayoa; Joel Bernanke; G K Scott; Nan Zhang; Jon Whitmore; J. Chen; J. Jordan; Anna L. Chu; Robert Sfeir; Elizabeth J. Thomson; Stacey Gabriel; S. Fisher; Y. Zhu; DiSaia Pj; H Gabra; D. Mutch; N. Petrelli; J.S. Rader; A.K. Sood; D. Bowtell; R. Penny; T. Shelton; CJ Creighton; Yali Wu; K. Cibulskis; A. Y. Sivachenko; C. H. Mermel; R. C. Onofrio; A. Crenshaw; A. Sivachenko; L. Chin; R. Nichol; S. Fisher; L. Ding; R. S. Fulton; D.C. Koboldt; T. Wylie; M. O'Laughlin; D. J. Dooling; R. Abbott; M. Wendl; H Broder Schmidt; C. S. Pohl; F. Vandin; E. Upfal; B. J. Raphael; Juinhua Zhang; J N Zhang; D. M. Absher; L. Waite; Sherlock Gv; J. D. Brooks; D. J. Weisenberger; T. Triche Jr; J. Buckley; J . Y . Han; S. Dorton; W-K Chang; K.A. Hoadley; S. Meng; Y. Shi; L. Li; Y. J. Turman; D. Zang; X. Zhou; J. Wu; M. D. Wilkerson; H. Carter; D. Kim; Samayoa Jc; R. Karchin; J. A. Bernanke; D. Haussler; J. M. Stuart; SC Benz; JZ Sanborn; C. J. Vaske; C. Szeto; C C Benz; G B D Scott; C. Yau; N. Zhang; R. Akbani; K A Baggerly; W. K. Yung; A Kahn; J. M. Greene; R. Sfeir; M. A. Jensen; J. Chen; J. Whitmore; S. Alonso; JV Jordan; A. Chu; Zhang Jh; M. Ferguson; P. J. Good; M. S. Guyer; B. Ozenberger; J. Peterson; E. Thomson

doi:10.1038/nature10166

Integrated genomic analyses of ovarian carcinoma

Комплексный геномный анализ карциномы яичника

Stephen B. Baylin, Tim Fennell, John N. Weinstein, Anil K. Sood, Peter J. Park, Liwei Lin, Rae Myers, W. K. Alfred Yung, Cameron Brennan, Houtan Noushmehr, Zack Sanborn, Chang‐Jiun Wu, Sachet A. Shukla, Giovanni Ciriello, Carrie Sougnez, Mary Iacocca, Daniel J. Weisenberger, Robert Penny, Charles M. Perou, D. Neil Hayes, Richard A. Gibbs, Eric S. Lander, Paul T. Spellman, Chris Sander, Matthew Meyerson, Stacey Gabriel, David Haussler, Christopher C. Benz, Brenda Rabeno, Eunjung Lee, Joseph Paulauskis, Troy Shelton, Mark E. Sherman, Peggy Yena, Saianand Balu, Katherine A. Hoadley, Michael D. Topal, Yevgeniy Antipin, Laetitia Borsu, Ethan Cerami, Marc Ladanyi, Alex Lash, Yupu Liang, Boris Reva, Nikolaus Schultz, Agnès Viale, Martin L. Ferguson, Mark S. Guyer, Bradley A. Ozenberger, Mark A. Jensen, A Kahn, Mike Noble, Kristian Cibulskis, Michael S. Lawrence, Robert C. Onofrio, Gordon Saksena, Lucinda Fulton, Elaine R. Mardis, Joshua M. Stuart, Rehan Akbani, David Van Den Berg, John Ngai, Elizabeth Purdom, Joseph R. Testa, Rui Jing, Andrey Sivachenko, Lisa L. Cook, Sherri Z. Millis, Janet S. Rader, David G. Huntsman, Keith Baggerly, Gavin Sherlock, Terence P. Speed, Joe W. Gray, Alex H. Ramos, George M. Weinstock, Mei Huang, G.B. Mills, J. M. Greene, Marcin Imieliński, Hani Gabra, Kristin Ardlie, Peter J. Good, Kay J. Park, Fanny Dao, Douglas A. Levine, Debra Bell, Jennifer Baldwin, Kim D. Delehaunty, Donna M. Muzny, Jane L. Peterson, Carl Morrison, Zhiyuan Hu, Daniel C. Koboldt, David A. Wheeler, Vincent Magrini, David J. Dooling, Catrina C. Fronick, Lora Lewis, Irene Newsham, Craig Pohl, David D.L. Bowtell, Andrew Berchuck, Benjamin P. Berman, Jeremy Chien, Leslie Cope, Rajiv Dhir, Michael D. McLellan, Nicholas J. Petrelli, Benjamin J. Raphael, Heather K. Schmidt, Karen Smith‐McCune, Douglas Voet, Matthew D. Wilkerson, Yuanyuan Xiao, Christopher Yau, Jin Xu, Alicia Hawes, Julian K. Wu, Dae Young Zang, Scott Morris, Christopher Harris, Carolyn C. Compton, Jinghui Zhang, Wendy Winckler, Ryan Demeter, Preethi H. Gunaratne, Craig H. Mermel, Cyriac Kandoth, John W. Wallis, Nathan D. Dees, Roeland Verhaak, Barry S. Taylor, Huyen Dinh, Steffen Durinck, Junwei Han, Charles Vaske, Timothy J. Triche, Rachel Karchin, Branimir I. Šikić, John R. Walker, Fabio Vandin, Henrik Bengtsson, Pierre Neuvial, William Schierding, Huy Nguyen, Raju Kucherlapati, Michael J. Birrer, Jireh Santibanez, Philip J. DiSaia, Pat Glenn, D. W. Cramer, Narciso Olvera, D. A. Levine, A. K. Godwin, Sandra Oršulić, Beth Y. Karlan, Jenny Gross, L Hartmann, Steve E. Kalloger, G. B. Mills, J. N. Weinstein, C. Morrison, D. Mutch, Michael J Hatfield, Paul Rhodes, Donata Grimm, Y.-Q. Wu, Jennifer Drummond, M. B. Morgan, C. Kovar, Kuo-Ching Chang, Lisa R. Treviño, C. J. Creighton, Gerald Fowler, M. Wang, J. G. Reid, G. Getz, C. H. Mermel, K. Cibulskis, R. W. Park, S. L. Carter, L. Chin, Andrew Crenshaw, Gaddy Getz, R. G. W. Verhaak, Sumeet Gupta, Diana Hubbard, James G. Herman, Stephen C. Benz, Christopher Szeto, Jingchun Zhu, Lakshmi R. Jakkula, Heidi S. Feiler, Robert E. Sheridan, Peter W. Laird, John G. Conboy, Joelle Kalicki, James M. Eldred, Lindsay L. Waite, Laura M. Heiser, James E. Korkola, James D. Brooks, Shelley Alonso, Parminder K. Mankoo, Fei Pan, R. Nichol, Jennifer Wilkinson, Theodora Bloom, T. Wylie, Q. Zhang, Ryan Abbott, M. Wendl, Dejun Shen, L. Ding, M. O’Laughlin, R. S. Fulton, S. M. Smith, Rebecca K. Wilson, James S. Hodges, E. Upfal, A. H. Ramos, Hangchao Zhang, Ilana Perna, Junihua Zhang, Lawrence S. Chin, Juinhua Zhang, Alex Protopopov, Gang Ren, Y. Liu, T. M. Kim, Narayanan Sathiamoorthy, Devin Absher, J. Z. Li, H. Shen, Jermya Buckley, Bahram Parvin, Raymond J. Cho, T. P. Speed, Helen Marr, Nihan Wang, Shannon Dorton, P. Neuvial, Yeseo Choi, Vanessa Wang, Wan Chang, Nick Socci, K. A. Hoadley, Peter L. Fielding, Rachel C. Myles, M. D. Topal, Y. Du, C. M. Perou, D. N. Hayes, L. Li, Erin Helms, Yidi J. Turman, Y. Eric Shi, Shiyu Meng, X. Zhou, H. Carter, D. Kim, J. Samayoa, Joel Bernanke, G K Scott, Nan Zhang, Jon Whitmore, J. Chen, J. Jordan, Anna L. Chu, Robert Sfeir, Elizabeth J. Thomson, Stacey Gabriel, S. Fisher, Y. Zhu, DiSaia Pj, H Gabra, D. Mutch, N. Petrelli, J.S. Rader, A.K. Sood, D. Bowtell, R. Penny, T. Shelton, CJ Creighton, Yali Wu, K. Cibulskis, A. Y. Sivachenko, C. H. Mermel, R. C. Onofrio, A. Crenshaw, A. Sivachenko, L. Chin, R. Nichol, S. Fisher, L. Ding, R. S. Fulton, D.C. Koboldt, T. Wylie, M. O'Laughlin, D. J. Dooling, R. Abbott, M. Wendl, H Broder Schmidt, C. S. Pohl, F. Vandin, E. Upfal, B. J. Raphael, Juinhua Zhang, J N Zhang, D. M. Absher, L. Waite, Sherlock Gv, J. D. Brooks, D. J. Weisenberger, T. Triche Jr, J. Buckley, J . Y . Han, S. Dorton, W-K Chang, K.A. Hoadley, S. Meng, Y. Shi, L. Li, Y. J. Turman, D. Zang, X. Zhou, J. Wu, M. D. Wilkerson, H. Carter, D. Kim, Samayoa Jc, R. Karchin, J. A. Bernanke, D. Haussler, J. M. Stuart, SC Benz, JZ Sanborn, C. J. Vaske, C. Szeto, C C Benz, G B D Scott, C. Yau, N. Zhang, R. Akbani, K A Baggerly, W. K. Yung, A Kahn, J. M. Greene, R. Sfeir, M. A. Jensen, J. Chen, J. Whitmore, S. Alonso, JV Jordan, A. Chu, Zhang Jh, M. Ferguson, P. J. Good, M. S. Guyer, B. Ozenberger, J. Peterson, E. Thomson

2011-06-28

SCID: 54.1/ju8xjdvu Discuss with AI

Cancer Genome AtlasTP53 mutationshigh-grade serous ovarian cancerhomologous recombination deficiencymolecular subtypes

Abstract (AI)

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes. Analyses delineated four ovarian cancer transcriptional subtypes, three microRNA subtypes, four promoter methylation subtypes and a transcriptional signature associated with survival duration, and shed new light on the impact that tumours with BRCA1/2 (BRCA1 or BRCA2) and CCNE1 aberrations have on survival. Pathway analyses suggested that homologous recombination is defective in about half of the tumours analysed, and that NOTCH and FOXM1 signalling are involved in serous ovarian cancer pathophysiology. The Cancer Genome Atlas (TCGA) project reports here its analysis of messenger RNA and microRNA expression, promoter methylation, DNA copy number and exome sequences in 489 high-grade serous ovarian adenocarcinomas. The analyses help establish new tumour subtypes. Among other insights is the finding that while the gene encoding p53 tumour suppressor is mutated in almost all tumours, nine other loci including NF1, BRCA1, BRCA2, RB1 and CDK12 carry recurrent albeit low-prevalence mutations. Homologous recombination is defective in about half of the tumours studied, and Notch and FOXM1 signalling are involved in the pathophysiology.

Key Findings

High-grade serous ovarian cancer harbors TP53 mutations in 96% of tumors, indicating near-universal disruption of the p53 pathway.

Homologous recombination appears defective in approximately half of tumors, while NOTCH and FOXM1 signaling contribute to serous ovarian cancer pathophysiology.

Integrated genomic profiling identified 113 significant focal DNA copy-number aberrations and promoter methylation events affecting 168 genes.

Molecular analyses defined four transcriptional, three microRNA, and four promoter-methylation subtypes, including a transcriptional signature associated with survival duration.

Nine additional genes, including NF1, BRCA1, BRCA2, RB1, and CDK12, carry statistically recurrent but individually low-prevalence somatic mutations.

Research Object

High-grade serous ovarian adenocarcinomas (489 tumour samples)

Research Subject

genomic and epigenomic molecular aberrations, tumour subtypes, pathway alterations, and their associations with survival and pathophysiology

Publication Details

DOI

10.1038/nature10166

Publication Date

2011-06-28

Journal

Publisher

ISSN

Cited by

8255

Open access PDF

https://www.nature.com/articles/nature10166.pdf

Access Type

Author Information

Authors

Stephen B. Baylin

Tim Fennell

John N. Weinstein

Anil K. Sood

Peter J. Park

Liwei Lin

Rae Myers

W. K. Alfred Yung

Cameron Brennan

Houtan Noushmehr

Zack Sanborn

Chang‐Jiun Wu

Sachet A. Shukla

Giovanni Ciriello

Carrie Sougnez

Mary Iacocca

Daniel J. Weisenberger

Robert Penny

Charles M. Perou

D. Neil Hayes

Richard A. Gibbs

Eric S. Lander

Paul T. Spellman

Chris Sander

Matthew Meyerson

Stacey Gabriel

David Haussler

Christopher C. Benz

Brenda Rabeno

Eunjung Lee

Joseph Paulauskis

Troy Shelton

Mark E. Sherman

Peggy Yena

Saianand Balu

Katherine A. Hoadley

Michael D. Topal

Yevgeniy Antipin

Laetitia Borsu

Ethan Cerami

Marc Ladanyi

Alex Lash

Yupu Liang

Boris Reva

Nikolaus Schultz

Agnès Viale

Martin L. Ferguson

Mark S. Guyer

Bradley A. Ozenberger

Mark A. Jensen

A Kahn

Mike Noble

Kristian Cibulskis

Michael S. Lawrence

Robert C. Onofrio

Gordon Saksena

Lucinda Fulton

Elaine R. Mardis

Joshua M. Stuart

Rehan Akbani

David Van Den Berg

John Ngai

Elizabeth Purdom

Joseph R. Testa

Rui Jing

Andrey Sivachenko

Lisa L. Cook

Sherri Z. Millis

Janet S. Rader

David G. Huntsman

Keith Baggerly

Gavin Sherlock

Terence P. Speed

Joe W. Gray

Alex H. Ramos

George M. Weinstock

Mei Huang

G.B. Mills

J. M. Greene

Marcin Imieliński

Hani Gabra

Kristin Ardlie

Peter J. Good

Kay J. Park

Fanny Dao

Douglas A. Levine

Debra Bell

Jennifer Baldwin

Kim D. Delehaunty

Donna M. Muzny

Jane L. Peterson

Carl Morrison

Zhiyuan Hu

Daniel C. Koboldt

David A. Wheeler

Vincent Magrini

David J. Dooling

Catrina C. Fronick

Lora Lewis

Irene Newsham

Craig Pohl

David D.L. Bowtell

Andrew Berchuck

Benjamin P. Berman

Jeremy Chien

Leslie Cope

Rajiv Dhir

Michael D. McLellan

Nicholas J. Petrelli

Benjamin J. Raphael

Heather K. Schmidt

Karen Smith‐McCune

Douglas Voet

Matthew D. Wilkerson

Yuanyuan Xiao

Christopher Yau

Jin Xu

Alicia Hawes

Julian K. Wu

Dae Young Zang

Scott Morris

Christopher Harris

Carolyn C. Compton

Jinghui Zhang

Wendy Winckler

Ryan Demeter

Preethi H. Gunaratne

Craig H. Mermel

Cyriac Kandoth

John W. Wallis

Nathan D. Dees

Roeland Verhaak

Barry S. Taylor

Huyen Dinh

Steffen Durinck

Junwei Han

Charles Vaske

Timothy J. Triche

Rachel Karchin

Branimir I. Šikić

John R. Walker

Fabio Vandin

Henrik Bengtsson

Pierre Neuvial

William Schierding

Huy Nguyen

Raju Kucherlapati

Michael J. Birrer

Jireh Santibanez

Philip J. DiSaia

Pat Glenn

D. W. Cramer

Narciso Olvera

D. A. Levine

A. K. Godwin

Sandra Oršulić

Beth Y. Karlan

Jenny Gross

L Hartmann

Steve E. Kalloger

G. B. Mills

J. N. Weinstein

C. Morrison

D. Mutch

Michael J Hatfield

Paul Rhodes

Donata Grimm

Y.-Q. Wu

Jennifer Drummond

M. B. Morgan

C. Kovar

Kuo-Ching Chang

Lisa R. Treviño

C. J. Creighton

Gerald Fowler

M. Wang

J. G. Reid

G. Getz

C. H. Mermel

K. Cibulskis

R. W. Park

S. L. Carter

L. Chin

Andrew Crenshaw

Gaddy Getz

R. G. W. Verhaak

Sumeet Gupta

Diana Hubbard

James G. Herman

Stephen C. Benz

Christopher Szeto

Jingchun Zhu

Lakshmi R. Jakkula

Heidi S. Feiler

Robert E. Sheridan

Peter W. Laird

John G. Conboy

Joelle Kalicki

James M. Eldred

Lindsay L. Waite

Laura M. Heiser

James E. Korkola

James D. Brooks

Shelley Alonso

Parminder K. Mankoo

Fei Pan

R. Nichol

Jennifer Wilkinson

Theodora Bloom

T. Wylie

Q. Zhang

Ryan Abbott

M. Wendl

Dejun Shen

L. Ding

M. O’Laughlin

R. S. Fulton

S. M. Smith

Rebecca K. Wilson

James S. Hodges

E. Upfal

A. H. Ramos

Hangchao Zhang

Ilana Perna

Junihua Zhang

Lawrence S. Chin

Juinhua Zhang

Alex Protopopov

Gang Ren

Y. Liu

T. M. Kim

Narayanan Sathiamoorthy

Devin Absher

J. Z. Li

H. Shen

Jermya Buckley

Bahram Parvin

Raymond J. Cho

T. P. Speed

Helen Marr

Nihan Wang

Shannon Dorton

P. Neuvial

Yeseo Choi

Vanessa Wang

Wan Chang

Nick Socci

K. A. Hoadley

Peter L. Fielding

Rachel C. Myles

M. D. Topal

Y. Du

C. M. Perou

D. N. Hayes

L. Li

Erin Helms

Yidi J. Turman

Y. Eric Shi

Shiyu Meng

X. Zhou

H. Carter

D. Kim

J. Samayoa

Joel Bernanke

G K Scott

Nan Zhang

Jon Whitmore

J. Chen

J. Jordan

Anna L. Chu

Robert Sfeir

Elizabeth J. Thomson

Stacey Gabriel

S. Fisher

Y. Zhu

DiSaia Pj

H Gabra

D. Mutch

N. Petrelli

J.S. Rader

A.K. Sood

D. Bowtell

R. Penny

T. Shelton

CJ Creighton

Yali Wu

K. Cibulskis

A. Y. Sivachenko

C. H. Mermel

R. C. Onofrio

A. Crenshaw

A. Sivachenko

L. Chin

R. Nichol

S. Fisher

L. Ding

R. S. Fulton

D.C. Koboldt

T. Wylie

M. O'Laughlin

D. J. Dooling

R. Abbott

M. Wendl

H Broder Schmidt

C. S. Pohl

F. Vandin

E. Upfal

B. J. Raphael

Juinhua Zhang

J N Zhang

D. M. Absher

L. Waite

Sherlock Gv

J. D. Brooks

D. J. Weisenberger

T. Triche Jr

J. Buckley

J . Y . Han

S. Dorton

W-K Chang

K.A. Hoadley

S. Meng

Y. Shi

L. Li

Y. J. Turman

D. Zang

X. Zhou

J. Wu

M. D. Wilkerson

H. Carter

D. Kim

Samayoa Jc

R. Karchin

J. A. Bernanke

D. Haussler

J. M. Stuart

SC Benz

JZ Sanborn

C. J. Vaske

C. Szeto

C C Benz

G B D Scott

C. Yau

N. Zhang

R. Akbani

K A Baggerly

W. K. Yung

A Kahn

J. M. Greene

R. Sfeir

M. A. Jensen

J. Chen

J. Whitmore

S. Alonso

JV Jordan

A. Chu

Zhang Jh

M. Ferguson

P. J. Good

M. S. Guyer

B. Ozenberger

J. Peterson

E. Thomson

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Cited by10

An integrated map of genetic variation from 1,092 human genomes2012 Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer2012 Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers2014 In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study2023 Epidemiology of ovarian cancer: a review2017 Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge2015 Mutational landscape and significance across 12 major cancer types2013 The Cancer Genome Atlas Pan-Cancer analysis project2013 Comprehensive genomic characterization of squamous cell lung cancers2012 Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing2012