Efficacy of pharmacological therapies in reducing outflow tract obstruction in patients with obstructive hypertrophic cardiomyopathy: a systematic review and meta-analysis

David G. Le Couteur; Steven J. Lester; Jeffrey B. Geske; Steve R. Ommen; Kamal Awad; Milagros Pereyra; Juan Farina; Girish Pathangey; Mohammed Tiseer Abbas; Isabel G. Scalia; Susan Wilanksy; Reza Arsanjani; Chadi Ayoub

doi:10.1093/ehjcvp/pvaf036

Efficacy of pharmacological therapies in reducing outflow tract obstruction in patients with obstructive hypertrophic cardiomyopathy: a systematic review and meta-analysis

Эффективность фармакологических препаратов в снижении обструкции выносящего тракта у пациентов с обструктивной гипертрофической кардиомиопатией: систематический обзор и мета-анализ

David G. Le Couteur, Steven J. Lester, Jeffrey B. Geske, Steve R. Ommen, Kamal Awad, Milagros Pereyra, Juan Farina, Girish Pathangey, Mohammed Tiseer Abbas, Isabel G. Scalia, Susan Wilanksy, Reza Arsanjani, Chadi Ayoub

2025-05-16

SCID: 54.1/htfqebwj Discuss with AI

beta-blockerscalcium channel blockerscardiac myosin inhibitorsdisopyramideleft ventricular outflow tract gradientmeta-analysisobstructive hypertrophic cardiomyopathysystematic review

Abstract (AI)

Pharmacological therapies effectively reduced LVOT gradients in oHCM patients to varying degrees, with disopyramide and CMIs showing the highest effect, followed by BBs and CCBs.

Key Findings

Beta blockers (BBs) and calcium channel blockers (CCBs) showed moderate reductions in LVOT gradients, less than disopyramide and CMIs.

Disopyramide and cardiac myosin inhibitors (CMIs) produced the largest reductions in LVOT gradients among evaluated therapies.

Pharmacological therapies reduce left ventricular outflow tract (LVOT) gradients in patients with obstructive hypertrophic cardiomyopathy (oHCM).

The magnitude of LVOT gradient reduction varies across different pharmacological classes.

Research Object

Patients with obstructive hypertrophic cardiomyopathy (oHCM) experiencing left ventricular outflow tract (LVOT) obstruction

Research Subject

Efficacy of pharmacological therapies (disopyramide, cardiac myosin inhibitors, beta-blockers, calcium channel blockers) in reducing LVOT gradients/outflow tract obstruction

Publication Details

DOI

10.1093/ehjcvp/pvaf036

Publication Date

2025-05-16

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https://academic.oup.com/ehjcvp/advance-article…

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Authors

David G. Le Couteur

Steven J. Lester

Jeffrey B. Geske

Steve R. Ommen

Kamal Awad

Milagros Pereyra

Juan Farina

Girish Pathangey

Mohammed Tiseer Abbas

Isabel G. Scalia

Susan Wilanksy

Reza Arsanjani

Chadi Ayoub

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References available in scid.ai4

RoB 2: a revised tool for assessing risk of bias in randomised trials2019 ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions2016 Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement2009 Bias in meta-analysis detected by a simple, graphical test1997